This book presents Proceedings of the 2021 Intelligent Systems Conference which is a remarkable collection of chapters covering a wider range of topics in areas of intelligent systems and artificial intelligence and their applications to the real world. The conference attracted a total of 496 submissions from many academic pioneering researchers, scientists, industrial engineers, and students from all around the world. These submissions underwent a double-blind peer-review process. Of the total submissions, 180 submissions have been selected to be included in these proceedings.
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